Originally developed as an anti-obesity drug candidate in the late 1990s, it has since found research applications in both metabolic studies and cartilage repair investigations
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In diet-induced obese (DIO) mouse models, NNMT inhibition led to approximately 35% reduction in white adipose tissue mass compared to controls
However, chronic GH treatment carries substantial risks, including glucose intolerance, insulin resistance, diabetes, cancer, and cardiovascular complications
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