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The documented weekly ladder is 0.25 mg (weeks 14) 0.5 mg (weeks 58) 1.0 mg (weeks 912) 1.7 mg (weeks 1316) 2.4 mg maintenance, roughly four weeks per step
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Many patients who start insulin can transition to GLP-1 medications or significantly reduce insulin doses when adding a GLP-1 agonist
It also affects motivation and decision-making in ways that make consistent dietary habits harder to maintain
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