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doi:10.1038/s41380-020-00981-3
Reduced selenium concentrations and glutathione peroxidase activity in preeclamptic pregnancies
Current ferroptosis research on the GCH1-BH4 axis remains confined to abundance/activity metrics (transcriptional control, protein level fluctuations, BH4 synthesis rate), leaving its post-translational landscape virtually unexplored
Interestingly, IR-deficient chondrocytes had increased IGF-1R levels and were more responsive to IGF-1 consistent with the notion that IGF-1/IGF-1R may compensate, at least in part, for loss of IR signaling
Briefly, cultured SCD erythroblasts or mouse spleen Ter119+ cells were harvested and lysed
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