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Consequently, on top of the beneficial effect of weight loss caused by GLP-1 analogues these drugs also cause a substantial reduction of the glycemic load (GL = carbohydrate intake X Glycemic index), which per se reduces hyperinsulinemia and causes weight loss [22], reduce diabetes risk [23], inflammation [24], and cardiovascular risk [25]

Beyond weight loss, GLP-1 medications offer additional health benefits, including: Reduction in visceral fat Improved insulin sensitivity Lower risk of heart disease, type 2 diabetes, and hypertension Evidence-Based Results The evidence supporting GLP-1 medications is substantial

Side effects are uncommon and usually minor (slight injection site soreness)

This claim requires significant caution, as long-term human data is not available to confirm durability of results

For analyses by molecular structure, each individual GLP-1RA type was separately matched 1:1 with DPP-4i comparators using propensity scores