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LY3437943 is a triagonist peptide activating GLP-1, GIP, and glucagon receptors in concert

These pathways are highly relevant to HS pathogenesis, which involves dysregulated innate immunity, chronic inflammation, and oxidative damage

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In the LOOK-AHEAD study, 5145 participants aged 4576 years (mean BMI 36 kg/m 2 ) with T2D were randomized to either calorie restriction or diabetes support and education intervention (controls) [33]