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By activating GLP-1 receptors, tirzepatide enhances glucose-dependent insulin secretion from pancreatic beta cells, suppresses inappropriate glucagon release, and slows gastric emptying
These examples highlight common patterns that guide decision-making
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The STEP 1 trial extension study, published in Diabetes, Obesity and Metabolism , found that participants who discontinued semaglutide after 68 weeks regained approximately two-thirds of their lost weight within one year of stopping treatment
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