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Pull off the paper tab from the outer needle shield
Importantly, the FDA labeling cautions against using semaglutide in patients with severe gastrointestinal disease, including severe gastroparesis
Without it, the increasing pressure inside the cartridge can crack the glass or push the plunger out
Lower body mass, different hepatic clearance, and higher GI sensitivity mean women typically respond at lower per-week totals and tolerate slower titration better
But, as mentioned, those studies were much too small to really know whether it is safe
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