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Role of GLP-1R binding kinetics The length of time that an agonist remains bound to its receptor, or residence time, is an important factor influencing the duration of drug action and a suggested driver of sustained signaling from internalized receptors 7
Important limitations: Tirzepatide is not indicated for type 1 diabetes or diabetic ketoacidosis and is not recommended for use with other GLP-1 receptor agonists
Semaglutide should be used in addition to a reduced-calorie diet and increased physical activity
Continue tesamorelin at 2mg daily
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