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Work suggests that gamma-glutamylcysteine, the immediate precursor of glutathione, can also perform a secondary antioxidant role and provide some protection from excess reactive oxygen species (58)

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However, a breakthrough came with the observation that TICs, rather than the bulk of differentiated tumor cells, thrive in 3D gels [23, 24], offering an opportunity to uncover signaling pathways specific to TIC growth and identify TIC-specific therapeutic targets

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