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Each route has different pharmacokinetic properties, impacting not only the half-life , but also the site of action and bioavailability
BPC-157 work centres on local angiogenic signalling, with Hsieh and colleagues (J Mol Med, 2017) reporting VEGFR2 upregulation and internalisation in human endothelial cells, and Chang and colleagues (J Appl Physiol, 2011) reporting increased focal adhesion kinase and paxillin phosphorylation in cultured rat tendon fibroblasts
In some cases, BPC-157 may also be available in oral or topical forms, though injections are often preferred for their direct and potent effects
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