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Obesity Action Coalition : Resources and support for individuals dealing with obesity.

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all comparisons are cross-study AOD-9604 human safety data / Limited Phase IIb obesity trial (N=536) showed mild, transient adverse events MOTS-c human safety data / Confined to small pilot studies and case series

As fat tissue grows and more NNMT is produced, higher amounts of hormones and pro-inflammatory signals are produced that are responsible for weight gain and other chronic diseases such as type 2 diabetes and cardiovascular disease. NNMT is responsible for converting nicotinamide (NA) into 1-methylnicotinamide (1-MNA), which takes it out of the NAD salvage pathway (see the diagram below)

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