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This lipidation promotes albumin binding, extending its plasma half-life to approximately one week, which allows for once-weekly dosing
Given the small sample size, absence of a comparator group, heterogeneous follow-up, and limitations inherent to retrospective data collection, no conclusions regarding glycemic efficacy, cardiovascular safety, or overall safety profile can be drawn
V.MirisolaV.SchleicherE.RomeoF.HhnekeC.et al (2008)
This falls well below the 10% safety threshold recommended for medications taken while breastfeeding, but again, results are only specific to that study
Sood expects them to show a positive outcome of this class of drugs as a whole
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