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Most recently in 2024, Joep Beumer and colleagues applied a multi-omics approach integrating genomics, transcriptomics, proteomics, organoid models, and gene editing to delineate the mechanism through which enteroendocrine cells sense ligands and regulate GLP-1 secretion (26)

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The latter tends to be smaller in size, but some authors consider Becker melanosis and congenital smooth muscle hamartoma to be two ends of a clinical spectrum (see Ch