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Its ability to activate downstream cAMP and PKA cascades serves as a reference for testing new analogues or combinatory compounds aimed at energy homeostasis modulation
Medium-chain fatty acids (MCFAs) (C8C10) bind the PPAR ligand binding domain in vitro, causing full inhibition of phosphorylation of PPAR by cyclin-dependent kinase 5 (cdk5) and reversal of IR in adipose tissue
Mouse models allow elegant mechanistic dissection, but the complexity of human MASHespecially in the context of metabolic heterogeneitydemands cautious interpretation
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