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The decision should account for the approved work plan, expected use, storage controls, record rules, and waste

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[4] Where published studies do not report a toxicological signal, the correct interpretation is not reported under the tested experimental conditions, not fully excluded. This distinction is important because many published studies involving 5-Amino-1MQ were designed primarily to evaluate NNMT-related biological mechanisms or model-specific metabolic endpoints, rather than to serve as dedicated toxicology programs