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Although there is a broad clinical spectrum of glutathione synthetase deficiency, manifestations usually include hemolytic anemia, often include metabolic acidosis, and sometimes include progressive neurologic symptoms as well as other systemic signs (eg, respiratory distress, sepsis, hyperbilirubinemia) (62
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The KwikPens have a dose knob, but Lilly labels them as delivering four fixed doses and does not provide a validated click-to-milligram conversion for fractional dosing
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Few molecules have reshaped the conversation around metabolic pharmacology as quickly as tirzepatide
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