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It binds to the heme containing enzyme guanylate cyclase, which activates the cyclic nucleotide cyclic-GMP [110]

These findings suggest a novel therapeutic pathway for IIH management, where GLP-1R agonists may offer dual benefits in weight reduction and headache relief [58]

Pregnancy: Teratogenic Effects

Drucker DJ, Buse JB, Taylor K, Kendall DM, Trautmann M, Zhuang D, et al

in vitro with chemically reactive metabolites derived from several drugs displaying idiosyncratic toxicity, including troglitazone, acetaminophen, clozapine, and diclofenac (Okada et al., 2011