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For many, the main hurdle is the potential for long waits for a GP appointment and subsequent NHS testing

NEJM reports both a treatment-regimen estimand (approximately 20.9% at 15 mg, which includes participants who stopped treatment) and an efficacy estimand (approximately 22.5%, for those who remained on treatment)

The evidence here is nuanced and worth exploring in detail

Yet for all its power, Retatrutide leaves certain physiological needs unaddressed

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