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As the supply shortfall has driven explosive growth in the black market for GLP-1 drugs, the FDA has temporarily allowed production of what are known as compounded versions of the drugs

However, the hypoglycemic events (OR value) were significantly higher when the combination therapy included a sulfonylurea than when there was no sulfonylurea, suggesting that sulfonylureas can dramatically increase the incidence of hypoglycemia events

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Centers for Medicare & Medicaid Services (CMS) , U.S

It downregulates reproductive hormones, slows thyroid output, and ramps up stress hormones