Role of Vitamin B12 in the Body Vitamin B12 is a water-soluble vitamin belonging to the B vitamin group and plays several important roles in the body, including: DNA Synthesis: It is involved in the synthesis of DNA, making it crucial for cell division and reproduction
The NHS advises that taking up to 2 mg (2000 micrograms) per day of vitamin B12 in supplements is unlikely to cause harm
Malabsorption (insufficient absorption of vitamin B12 in the intestine) due to insufficient production of intrinsic factor (a protein produced in the lining of the stomach that is needed to absorb vitamin B12), disorders in the end section of the ileum (part of the small intestine), such as sprue, fish tapeworm infestation or blind loop syndrome (change in the course of the intestine after gastric surgery)
In proof-of-concept studies, NNMT inhibitors (NNMTis) have demonstrated promise as potential treatments for obesity and obesity-related metabolic comorbidities (e.g., T2D, fatty liver) 8,9,13
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