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Rule out other conditions Prolonged diarrhea might not always be linked directly to semaglutide

Platelets expressing P-selectin can interact with leukocytes expressing PSGL-1 or with endothelial PSGL-1 ligands

The most commonly reported side effects were gastrointestinal, including nausea, vomiting, diarrhoea, and constipation, which were generally mild to moderate and most frequent during the dose-escalation phase