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Interventions targeting early stages of AD are considered critical for delaying disease progression and reducing long-term disability
Five-year follow-up data presented at the AAOS 2026 meeting indicated that GLP-1 users had a significantly higher risk of osteoporosis than matched controls (4.1% to 3.2%)
Written informed consent by the patients was waived due to a retrospective nature of our study
We and others have demonstrated that GLP-1R signalling elevated ATP levels 38, 39 , strengthening the hypothesis that the incretin hormone may promote -cell function through regulation of energy metabolism, especially considering the central role that ATP generation and an increase in ATP/ADP ratio play during GSIS
The mechanisms responsible for this dichotomy remain to be established
