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A 2024 safety review in ScienceDirect noted that tirzepatide may have slightly better GI tolerability than semaglutide, likely because of its dual mechanism ( ScienceDirect , 2024)

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Patients should carefully follow dosing instructions provided by their prescribing clinician and compounding pharmacy, and contact their provider immediately if unsure about proper dosing

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But the addition of glucagon receptor agonism overwhelms the GIP benefit

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And it helps maintain satiety between meals, working with rather than against the GLP-1 medication mechanism

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