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The role of the IGF-1 signaling cascade in muscle protein synthesis and anabolic resistance in aging skeletal muscle
GLP-1 receptor agonists cause fatigue primarily through indirect mechanisms including substantial caloric restriction from appetite suppression, gastrointestinal side effects leading to dehydration and nutritional deficits, and metabolic adaptation during weight loss
Recent developments: April 2026, The FDA proposed excluding semaglutide, tirzepatide, and liraglutide from the 503B bulks list, potentially limiting large-scale compounding activities
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