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The buffering genetic interaction revealed from our CRISPR screen 13 allowed further extending the finding by demonstrating a functional coordination of mitochondrial glutathione uptake (mediated by SLC25A39) and mitochondrial iron import (mediated by SLC25A37) in supporting OXPHOS
GHK, CuCl 2 and Cu(OAc) 2 were used at a final concentration of 58 M and 580 M
Because it is active at such small amounts, potential side effects tend to be mild and transient
10.1213/ANE.0b013e3182860fc9 11 BartzokisG.BecksonM.LuP
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