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SOC 2 Type II
has advisory roles (compensated, institutional) with Astellas, AstraZeneca, Bayer, Janssen, Merck, Sharp and Dohme (MSD), Pfizer, Roche and Sanofi Aventis, receives research support (institutional) from Janssen and Teva, receives travel support for medical conferences from Astellas, Bayer, Janssen and Sanofi Aventis, and serves as a speaker (compensated, institutional) for Bayer and Astellas
These agents mimic the biological action of the native incretin hormone GLP-1 but are structurally modified to resist degradation by the enzyme dipeptidyl peptidase 4 (DPP-4), thereby extending their half-life and duration of action (Zheng et al., 2024
R., & LEADER Publication Committee on behalf of the LEADER Trial Investigators
Global estimates for the year 2035 show that no apparent reversal of the trend is coming, with 1.9 billion people expected to be affected
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