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Available from: [Last accessed on 2022 Apr 25] [Google Scholar] Global prevalence and burden of depressive and anxiety disorders in 204 countries and territories in 2020 due to the COVID-19 pandemic
The subsections below systematically evaluate how chitosan-based DOX platforms harness each target, highlighting innovations in coreshell architecture, stimuli-responsive release, and resistance-overcoming co-delivery that advance beyond simple ligand attachment toward functionally integrated therapeutic systems
These active sites react with peroxide to make selenenic acid (Se-OH), which is then reduced into glutathione (GSH) by the glutathione reductase (GR) enzyme to produce glutathiolated selenol (Se-SG) intermediate
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