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It was found that semaglutide, a long-acting GLP-1RA, could improve symptoms caused by sepsis, reduce body temperature, and decrease the bacterial load in multiple organs, along with the levels of inflammatory factors in plasma and lungs.423 These findings further confirmed the central role of the CNS in regulating the anti-inflammatory effects of GLP-1RAs, highlighting the potential application of GLP-1RAs in anti-inflammatory treatment

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Thus, depending on the stage of obesity, ROS can be generated by three distinct mechanisms: i.e., NOX4, NOX2, and mitochondria

Ongoing monitoring should include thyroid function testing at appropriate intervals, particularly in patients experiencing significant weight loss or after tirzepatide dose increases

PubChem CID 171397054 Lyophilisation & Stability Cagrilintide is supplied as a lyophilised white powder, sealed under controlled conditions