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A dual GLP-1-estrogen conjugate (GE) designed to selectively deliver estrogen to GLP-1R + cells induced substantial weight loss in mice without evidence of systemic estrogenic effects, as assessed by uterine weight and growth of estrogen-dependent breast cancer xenografts (Finan et al., 2012)

The article separates loss of potency from loss of sterility

As more clinicians prescribe these therapies, its vital to understand how GLP1s control appetite and cravings and how to clearly explain this effect to patients navigating hunger, habits, and long-term lifestyle changes

The researchers independently matched the groups by demographic variables, weight, BMI and other factors using a 1:1 nearest neighbor greedy matching algorithm

Most patients benefit from using a different site each week, creating a simple rotation pattern they can follow month after month