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GSH in Cancer Dual Roles in Carcinogenesis and Drug Resistance (PubMed, 2019) Elevated Tumour GSH as a Driver of Chemotherapy Resistance A comprehensive review published on PubMed examined GSHs dual roles in cancer biology chemopreventive in normal cells through carcinogen detoxification by GST, and pathogenic in tumour cells where elevated GSH levels are associated with tumour progression and increased resistance to chemotherapeutic drugs and radiotherapy
ROS production has been found to increase with exercise, thus augmenting the amount of oxidative damage induced to lipids, proteins and DNA [1, 2, 22, 23]
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Apart from replenishing the glutathione, NAC has been shown to optimize immune health by influencing several macrophage, neutrophils and lymphocyte function
Jacquier-Sarlin and Polla, 1996
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