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572 RNA sequencing also has identified splice site mutations in mitochondrial diseases

The mPTP opens in response to calcium and/or oxidative stress and allows transit of molecules of up to 1,500 Da from inside mitochondria to the cytosol

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These were predominantly dose-dependent and most prominent during dose escalation

Currently, there is only one drug available on the market to treat schistosomiasis, Praziquantel (PZQ), which has limited activity against juvenile worms