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Common Side Effects and Safety Considerations Nausea is the most frequently reported adverse effect with all GLP-1 receptor agonists, occurring in roughly 44% of semaglutide users in STEP-1 and typically peaking during dose escalation

4 Based on the new information presented here, we would additionally suggest that there is a low threshold to refer patients with clEDS and gastrointestinal complaints to a gastroenterologist

Drucker DJ, Rosen CF

GLP-1 Signaling at the Intersection of Metabolism and Reward The gut and brain communicate via the vagus nerve, so gut health directly impacts mood, anxiety, and neurodegenerative conditions

This may be treated by taking L-carnitine supplements or eating foods rich in L-carnitine (e.g., meat, poultry, fish, and dairy products), or the patient may need to stop taking valproic acid