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Its advisable to start with a lower dose and gradually increase if needed, always under the guidance of a healthcare professional
[172] In cases where mild withdrawal symptoms do occur, they can be avoided by tapering the dose
In HG-induced mouse renal podocytes (MPC5) and STZ-induced C57BL/6 mouse models, the LncRNA SNHG17 was found to be elevated in DM mice and HG-treated MPC5, and further studies revealed that lncRNA SNHG17 knockdown reduced podocyte apoptosis by regulating Mst1 degradation and promoting Parkin-dependent mitophagy [114]
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