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This information, combined with clinical assessment, may support more informed medication selection and realistic outcome expectations

Upon recognition of MSU crystals, the NLRP3 inflammasome is activated, leading to the cleavage of pro-inflammatory cytokines, specifically interleukin-1 (IL-1) and interleukin-18 (IL-18)

Currently, no evidence suggests tirzepatide causes or worsens MS, but careful monitoring and coordinated care between neurology and primary care teams remain important for optimal outcomes

These modifications prevent IGF-1 LR3 from binding to IGF-binding proteins (IGFBPs), which normally deactivate regular IGF-1 within minutes

Accessed February 15, 2026