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Several reasons may explain the observation that the mean treatment difference was 12.5% in STEP 1 and 8.7% in SELECT
They have more subsurface material waiting to be cleared
People with pernicious anemia or significant gastrointestinal absorption issues may be placed on injections for this reason
An overdose of vitamin B12 through diet is hardly possible and also not known, since the required transport protein IF (intrinsic factor) and absorption via the intestinal mucosa are two major barriers
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