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Despite these conflicting data, AOXs were used in the treatment of RM with various claims of success

Flare-ups often coincide with the consumption of histamine-laden foods or environmental allergens

Firstly, activated NF-B and NLRP3 inflammasome in DN promotes inflammation and increases fibronectin and collagen deposition in kidney, 41,42 leading to thickening glomerular basement membrane, glomerular sclerosis, podocyte damage, and ultimately kidney fibrosis

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Structural changes in collagen and elastin networks require sustained signaling to manifest fully