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For example, drug-resistant breast cancer cells secrete TNF-, which triggers mTORC1-FOXK1 activation in TAMs and facilitates the M2 polarization of TAMs, enhancing the secretion of more CCL2 to create a positive feedback system

These effects typically resolve within 23 weeks and don't indicate inefficacy

Sticky and smelly stools are typical symptoms of nutrient malabsorption, and it might indicate that there is damage in the small intestine, not producing enough pancreatic enzymes, HIV, or liver disease

Also, mTORC1 activates the ribosomal protein S6 kinase beta-1 (S6K1) and the eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1), promoting the translation of MCL-1 mRNA on ribosomes and the synthesis of Mcl-1 [301]