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Alternatives and Next Steps for Weight or Hormone Management MHRA-authorised weight-management options include semaglutide (Wegovy), liraglutide (Saxenda), orlistat, and tirzepatide (Zepbound)
However, GLP1/E reduced testosterone levels in PNA mice, an effect mimicked by monotherapies and metformin (Fig
Clinical Evidence: Semaglutide and Cardiovascular Blood Pressure Outcomes The SUSTAIN-6 trial, which followed over 3,000 patients with type 2 diabetes, documented that weekly semaglutide reduced the risk of major adverse cardiovascular events by 26% compared to placebo
Long-acting agents might work better for long-term use, especially for patients who might develop movement problems in their digestive system
With recent FDA enforcement against misleading direct-to-consumer prescription drug advertising, telehealth and DTC platforms that advertise GLP-1 products will likely need more careful legal / regulatory oversight of their ad claims, especially around benefit claims and safety disclosures
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