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The GLP-1 receptor agonist component is considered the likely contributor to gastrointestinal side effects, based on established class-effect data from semaglutide and tirzepatide
The next question was how to keep a peptide alive in the bloodstream long enough to work with less frequent dosing
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These side effects are temporary and usually fade on their own
[63] Research continued, and in 1993, Michael Nauck managed to infuse GLP-1 into people with type 2 diabetes, stimulating insulin while inhibiting glucagon and bringing blood glucose to normal levels
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