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In previous studies, FOXO4 and p53 have been shown to interact, a process that inhibits the pro-apoptotic role of p53 by restraining its nuclear exclusion, thereby promoting cell survival

Beyond detoxification and antioxidant activity, glutathione is involved in other important processes, including: Regenerating other antioxidants, such as vitamin C and vitamin E, improving their effectiveness Supporting energy production within cells Aiding in protein synthesis and enzyme function Maintaining optimal glutathione levels is essential for overall health

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Indeed, we observed a similar NAD + and NADH ratio between the ghd3 / gdh3 mutant and the wild-type when grown in arginine medium (Supplementary Fig