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Key variants in genes like MC4R affect both weight loss rate and metabolic stress, indirectly predicting telogen effluvium susceptibility

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Supplements like ashwagandha gummies, moringa and cortisol-reduction aids point to sustained interest in adaptogenic and natural stress-relief tools, supporting the need for calm, focus and hormonal harmony in high-stress environments

To elucidate the molecular mechanisms by which tirzepatide, a GIPR/GLP-1R dual agonist, and peptide 20, a GIPR/GLP-1R/GCGR triagonist, manifest their multiplexed pharmacological actions over monoagonists such as semaglutide, we determine cryo-electron microscopy structures of tirzepatide-bound GIPR and GLP-1R as well as peptide 20-bound GIPR, GLP-1R and GCGR