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In terms of other disorders affecting the brain there was a small but statistically significant reduced risk of seizures and of dementia in those taking GLP1RAs

Weight loss trajectory after restarting generally follows a pattern of initial stabilization (stopping further weight regain), followed by renewed weight loss as the dose is optimized

In a Phase 2 randomised controlled trial published in The New England Journal of Medicine (Jastreboff et al., 2023), participants without type 2 diabetes receiving the highest doses of retatrutide achieved mean body weight reductions of approximately 24% over 48 weeks

Routine screening tools such as the PHQ9 remain essential for identifying depression, especially in patients managing chronic illnesses like diabetes

doi: 10.1210/jc.2018-00953