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Without knowing the target, the mechanism of action remains incompletely understood, and it is not possible to optimize the peptide-receptor interaction or predict off-target effects

Seely, Elisabetta Patorno, Sonia Hernndez-Daz, JAMA Internal Medicine, online December 11, 2023, doi: 10.1001/jamainternalmed.2023.6663

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If the previous regimen caused diarrhea or nausea, XR may be considered for tolerability, but it is not suitable for every situation