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Bank of America Securities (BofA) warned that the offering could pressure Hims & Hers weight-loss revenues over the longer term, particularly among patients seeking lower-cost prescription renewals
A 12-week trial of patients receiving semaglutide demonstrated an 11.85% reduction in body weight from baseline, greater than that seen with diet and exercise alone
95% CI, 0.68-1.72, P 50% indicates significant statistical heterogeneity among studies
Furthermore, its tolerability profile, which includes weight gain, edema/fluid retention, fractures, and (rarely) bladder cancer in long-term use, could hinder its potential repositioning for depression [173]
Some patients have some degree of nausea for the first four to five weeks of treatment, but in many cases, symptoms disappear within eight days of beginning treatment
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