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Approximately 1% of oral B12 is absorbed through passive diffusion, independent of intrinsic factor, making high doses effective even in pernicious anaemia
For example, symptoms such as tiredness or pins and needles may be linked to B12 deficiency, but they may also be linked to other medical issues
It also makes the treatment easier for patients
How quickly will you feel a difference
It could point to several things: A different cause: your fatigue might stem from thyroid problems, iron deficiency, or sleep apnea rather than B12
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