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But only the R-isomer (R-ALA) is naturally produced in the body and actively participates in mitochondrial energy metabolism.12 Some studies suggest that R-ALA may be more bioavailable than standard racemic ALA though the clinical significance of this difference is still under investigation.17 In addition, anecdotal reports and small studies indicate that R-ALA may be easier on digestion, with fewer gastrointestinal side effects than standard racemic ALA, especially at higher doses.18 However, R-ALA is chemically unstable on its own

such as the polysaccharidic capsule (Nikulin et al., 2006

et al., 2020

The moment water is reintroduced during reconstitution, the peptide becomes biologically and chemically active again and correspondingly far more vulnerable to heat, light, microbial growth, and hydrolysis

doi:10.1016/b978-1-4377-0774-8.10017-x