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doi: 10.1016/S0006-2952(03)00504-5 20

Altered expression of glutamate transporters, including the cystineglutamate transporter (xCT) system, increases concentrations of extracellular glutamate, which contribute to epileptic discharge, tumour proliferation and peripheral excitotoxicity

That showed basically binding of either dynorphin or whatever ligand to the kappa opioid receptor, basically sensitizes the Mu opioid receptor to the feel-good endorphins, and also changes

This study provides evidence that OB GLP-1 signalling engages a top-down neural mechanism to control insulin secretion via the SNS