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The glucagon receptor activation (paradoxically) adds metabolic benefits when paired with GLP-1 and GIP , such as promoting energy expenditure and fat oxidation, possibly combating the decrease in basal metabolic rate that accompanies weight loss, and helping reduce liver fat
The exceptions are kisspeptin (dosed per kg in research settings) and some practitioners who adjust TB-500 loading doses for users over 250 lbs (increasing from 5 mg to 7.5 mg twice weekly)
Weight loss and menstrual cycle: clinical and endocrinological evaluation
(Side note: from a medical perspective, its really exciting that these medications may have applications beyond weight loss alone
2019 Jul 1;160(7):1600-1612
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