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DiNicolantonio, J.J., Bhutani, J., McCarty, M.F., et al
Larger series showing high rates of successful desenzitiation to TMP-SMX in those with previously reported sulfonamide adverse drug reactions
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Metabolic pathways included purine metabolism (involved metabolites: guanine, hypoxanthine, guanosine, adenosine and deoxyguanosine), glutathione metabolism (involved metabolites: GSSG and NADP), biosynthesis of various other secondary metabolites (involved metabolites: lysine and phenylalanine), nicotinate and nicotinamide metabolism (involved metabolites: 1-methylnicotinamide and NADP), and aminoacyl-tRNA biosynthesis (involved metabolites: lysine and phenylalanine)
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