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Compounds Imatinib (HY-15463) and Ponatinib (HY-12047) were from MedChemExpress(MCE)

Resting energy expenditure, substrate oxidation rate Resting energy expenditure (REE) was calculated using Weirs equation 53 and glucose and fat oxidation according to the equation by Frayn 54 as listed below VCO 2 and VO 2 are gaseous exchanges (L/min) obtained from the calorimeter, and N is the urinary nitrogen excretion (g/min)

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We measured mitochondrial DNA using the PCR assay described previously (Roach et al., 2023b), and cellular glutathione levels using the Glutathione Colorimetric Detection Kit (catalog #K006-H1, Arbor Assays, Ann Arbor, MI, United States)

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